Vaccine-policy and Testing

SYSVAC: Development of a database of vaccine-policy relevant systematic reviews

To make it easier for vaccine decision makers to identify systematic reviews, this project has created a database of references relevant to vaccine policy. Several databases are searched regularly for vaccine references, which are then screened with specified inclusion criteria to ensure only those relevant are included. Keywords are added to included references for more precise searching.

The National Institute for Health Research (NIHR) Health Protection Research Unit in Immunisation is a unique partnership between the London School of Hygiene & Tropical Medicine and Public Health England creating a dynamic fusion of academic research and public health implementation that rapidly translates scientific advances in immunization into measurable benefits for society

The immunisation system is one of the most powerful tools available to protect the health of the population and, in England, it is one of the most highly developed in the world. Each new vaccine is assessed by monitoring the amount of disease that occurs in the population, estimating the effect of the vaccine on that disease burden using mathematical models, and calculating the costs and the health benefits of the vaccine programme using economic analyses.

The HPRU sustains and refines this process by optimising the tools for surveillance and evaluation and increasing health benefits across the whole of society. We use state-of-the-art electronic health record systems to streamline the evaluation of disease burden in the population and produce rapid assessments of vaccine impact and vaccine safety. We explore the differences in uptake of vaccines in different groups and research the factors driving these differences in order to improve vaccine coverage and generate an equitable health protection system through immunization. We investigate the delivery of vaccines through general practices, pharmacies and schools to work out the most efficient methods for giving each type of vaccine and we examine the way the NHS works with society in order to optimize vaccination uptake.

The results of our work are delivered rapidly to the Joint Committee on Vaccination and Immunisation, the policy-setting body within the Department of Health, in order to impact quickly on immunization policy and optimize the vaccine programme in England and Wales.

Key project areas

  • Vaccination

Study design

  • Review database

Countries

  • Global

Dates

  • 2014-2018

Principal Investigator(s)

  • Helen Burchett

Funding Source

  • NIHR

Project Partners

  • PHE/AMP

Other Staff Involved:

  • Mark Jit, Silke Fernandes, Anthony Scott

 

ACT consortium RDTs in Context: Cross-study analysis of reasons for variation in malaria RDT (Rapid Diagnostic Tests) uptake and adherence

This analysis used qualitative, quantitative and contextual data to explore reasons for variation in provider’s uptake of and adherence to malaria RDTs.  Twenty-eight study arms, from 10 ACT consortium studies, were included in this comparative case study.

Key project areas

  • Malaria Rapid Diagnostic Tests

Study design

  • cross-study analysis

Countries

  • Ghana, Cameroon, Nigeria, Afghanistan, Tanzania

Dates

  • 2013 – 2016

Principal Investigator(s)

  • Helen Burchett, Clare Chandler

Funding Source

  • Bill and Melinda Gates Foundation

Other Staff Involved

  • Baptiste Leurent

 

Lessons Learnt from HPV Demonstration Projects and Introductions

This study aimed to synthesise lessons learnt from HPV demonstration projects and national introductions. We conducted a systematic search for published literature, sourced a large amount of grey literature and interviewed key stakeholders to fill gaps in the literature.

Key project areas

  • HPV vaccination

Study design

  • systematic review and interviews

Countries

  • multiple

Dates

  • 2014-2015

Principal Investigator(s)

  • Debby Watson-Jones & Scott LaMontagne (PATH)

Funding Source

  • Bill and Melinda Gates Foundation

Project Partners

  • PATH

Other Staff Involved:

  • Helen Burchett, Debby Watson-Jones, Sandra Mounier-Jack, Natasha Howard, Kate Gallagher

For more information on these projects please contact Helen Burchett.

Comments are closed.